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Peer-reviewed Articles

Highlighted Manuscripts

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2024

Stearoyl-CoA desaturase-1: a potential therapeutic target for neurological disorders. Melanie Loix, Sam Vanherle, Marta Turri, Stephan Kemp, Karl J. L. Fernandes, Jerome J. A. Hendriks & Jeroen F. J. Bogie  Molecular Neurodegeneration volume 19, number: 85 (2024)

Identification of a 5-Plex Cytokine Signature that Differentiates Patients with Multiple Systemic Inflammatory Diseases. Hoste L, Meertens B, Ogunjimi B, Sabato V, Guerti K, van der Hilst J, Bogie J, Joos R, Claes K, Debacker V, Janssen F, Tavernier SJ, Jacques P, Callens S, Dehoorne J, Haerynck F. Inflammation. 2024 Nov 12. doi: 10.1007/s10753-024-02183-3. 

 Lipids in inflammasome activation and autoinflammatory disorders. Wouters F, van der Hilst J, Bogie J. J Allergy Clin Immunol. 2024 Jan;153(1):1-11.

The ubiquitous role of ubiquitination in lipid metabolism. Melanie Loix, Noam Zelcer, Jeroen F J Bogie, Jerome J A Hendriks. Trends Cell Biol. 2023 Sep 26:S0962-8924(23)00192-7. doi: 10.1016/j.tcb.2023.09.001. Online ahead of print.

2022

Targeting lipophagy in macrophages improves repair in multiple sclerosis. Haidar M, Loix M, Vanherle S, Dierckx T, Vangansewinkel T, Gervois P, Wolfs E, Lambrichts I, Bogie JFJ, Hendriks JJA. Autophagy. 2022 Nov;18(11):2697-2710. doi: 10.1080/15548627.2022.2047343. Epub 2022 Mar 14.

Phloretin enhances remyelination by stimulating oligodendrocyte precursor cell differentiation. Dierckx T, Vanherle S, Haidar M, Grajchen E, Mingneau F, Gervois P, Wolfs E, Bylemans D, Voet A, Nguyen T, Hamad I, Kleinewietfeld M, Bogie JFJ, Hendriks JJA. Proc Natl Acad Sci U S A. 2022 Nov 16;119(46):e2120393119. doi: 10.1073/pnas.2120393119. Epub 2022 Nov 7.

The ApoA-I mimetic peptide 5A enhances remyelination by promoting clearance and degradation of myelin debris. Vanherle S, Jorissen W, Dierckx T, Loix M, Grajchen E, Mingneau F, Guns J, Gervois P, Lambrichts I, Dehairs J, Swinnen JV, Mulder MT, Remaley AT, Haidar M, Hendriks JJA, Bogie JJF. Cell Rep. 2022 Nov 8;41(6):111591. doi: 10.1016/j.celrep.2022.111591.

Perilipin-2 limits remyelination by preventing lipid droplet degradation. Loix M, Wouters E, Vanherle S, Dehairs J, McManaman JL, Kemps H, Swinnen JV, Haidar M, Bogie JFJ, Hendriks JJA. Cell Mol Life Sci. 2022 Sep 13;79(10):515. doi: 10.1007/s00018-022-04547-0.

Protein Lipidation by Palmitate Controls Macrophage Function. Guns J, Vanherle S, Hendriks JJA, Bogie JFJ. Cells. 2022 Feb 6;11(3):565. doi: 10.3390/cells11030565.

2023

Extracellular vesicle-associated cholesterol supports the regenerative functions of macrophages in the brain. Sam Vanherle, Jeroen Guns, Melanie Loix, Fleur Mingneau, Tess Dierckx , Flore Wouters, Koen Kuipers, Tim Vangansewinkel, Esther Wolfs, Paula Pincela Lins, Annelies Bronckaers, Ivo Lambrichts, Jonas Dehairs, Johannes V Swinnen, Sanne G S Verberk, Mansour Haidar, Jerome J A Hendriks, Jeroen F J Bogie. J Extracell Vesicles. 2023 Dec;12(12):e12394. doi: 10.1002/jev2.12394.

Fatty acid elongation by ELOVL6 hampers remyelination by promoting inflammatory foam cell formation during demyelination. Aida V Garcia Corrales, Sanne G S Verberk, Mansour Haidar, Elien Grajchen, Jonas Dehairs, Sam Vanherle, Melanie Loix, Tine Weytjens, Pascal Gervois, Takashi Matsuzaka, Ivo Lambrichts, Johannes V Swinnen, Jeroen F J Bogie, Jerome J A Hendriks. Proc Natl Acad Sci U S A
. 2023 Sep 12;120(37):e2301030120. doi: 10.1073/pnas.2301030120. 

Fatty acid desaturation by stearoyl-CoA desaturase-1 controls regulatory T cell differentiation and autoimmunity. Grajchen E, Loix M, Baeten P, Côrte-Real BF, Hamad I, Vanherle S, Haidar M, Dehairs J, Broos JY, Ntambi JM, Zimmermann R, Breinbauer R, Stinissen P, Hellings N, Verberk SGS, Kooij G, Giera M, Swinnen JV, Broux B, Kleinewietfeld M, Hendriks JJA, Bogie JFJ. Cell Mol Immunol. 2023 Apr 12. doi: 10.1038/s41423-023-01011-2. Online ahead of print.PMID: 37041314

Sterol-regulated transmembrane protein TMEM86a couples LXR signaling to regulation of lysoplasmalogens in macrophages. van Wouw SAE, van den Berg M, El Ouraoui M, Meurs A, Kingma J, Ottenhoff R, Loix M, Hoeksema MA, Prange K, Pasterkamp G, Hendriks JJA, Bogie JFJ, van Klinken JB, Vaz FM, Jongejan A, de Winther MPJ, Zelcer N. J Lipid Res. 2023 Feb;64(2):100325. doi: 10.1016/j.jlr.2022.100325. Epub 2022 Dec 31.

Microglia regulate central nervous system myelin growth and integrity. McNamara NB, Munro DAD, Bestard-Cuche N, Uyeda A, Bogie JFJ, Hoffmann A, Holloway RK, Molina-Gonzalez I, Askew KE, Mitchell S, Mungall W, Dodds M, Dittmayer C, Moss J, Rose J, Szymkowiak S, Amann L, McColl BW, Prinz M, Spires-Jones TL, Stenzel W, Horsburgh K, Hendriks JJA, Pridans C, Muramatsu R, Williams A, Priller J, Miron VE. Nature. 2023 Jan;613(7942):120-129. doi: 10.1038/s41586-022-05534-y. Epub 2022 Dec 14.

Recent Insights in Pyrin Inflammasome Activation: Identifying Potential Novel Therapeutic Approaches in Pyrin-Associated Autoinflammatory Syndromes. Wouters F, Bogie J, Wullaert A, van der Hilst J. J Clin Immunol. 2023 Dec 22;44(1):8.

2021

Carnosine quenches the reactive carbonyl acrolein in the central nervous system and attenuates autoimmune neuroinflammation. Spaas J, Franssen WMA, Keytsman C, Blancquaert L, Vanmierlo T, Bogie J, Broux B, Hellings N, van Horssen J, Posa DK, Hoetker D, Baba SP, Derave W, Eijnde BO. J Neuroinflammation. 2021 Nov 5;18(1):255. doi: 10.1186/s12974-021-02306-9.

Lipophagy: a new player in CNS disorders. Haidar M, Loix M, Bogie JFJ, Hendriks JJA. Trends Endocrinol Metab. 2021 Nov;32(11):941-951. doi: 10.1016/j.tem.2021.08.010. Epub 2021 Sep 21.

Liver X receptor beta deficiency attenuates autoimmune-associated neuroinflammation in a T cell-dependent manner. Bogie JFJ, Vanmierlo T, Vanmol J, Timmermans S, Mailleux J, Nelissen K, Wijnands E, Wouters K, Stinissen P, Gustafsson JÅ, Steffensen KR, Mulder M, Zelcer N, Hendriks JJA. J Autoimmun. 2021 Nov;124:102723. doi: 10.1016/j.jaut.2021.102723. Epub 2021 Sep 1.

Fatty Acid Synthesis in Glial Cells of the CNS. Garcia Corrales AV, Haidar M, Bogie JFJ, Hendriks JJA. Int J Mol Sci. 2021 Jul 29;22(15):8159. doi: 10.3390/ijms22158159.

Phloretin suppresses neuroinflammation by autophagy-mediated Nrf2 activation in macrophages. Dierckx T, Haidar M, Grajchen E, Wouters E, Vanherle S, Loix M, Boeykens A, Bylemans D, Hardonnière K, Kerdine-Römer S, Bogie JFJ, Hendriks JJA. J Neuroinflammation. 2021 Jul 4;18(1):148. doi: 10.1186/s12974-021-02194-z.

2020

Altered PPARγ Expression Promotes Myelin-Induced Foam Cell Formation in Macrophages in Multiple Sclerosis. Wouters E, Grajchen E, Jorissen W, Dierckx T, Wetzels S, Loix M, Tulleners MP, Staels B, Stinissen P, Haidar M, Bogie JFJ, Hendriks JJA. Int J Mol Sci. 2020 Dec 7;21(23):9329. doi: 10.3390/ijms21239329.

CNS delivery of anti-CD52 antibodies modestly reduces disease severity in an animal model for multiple sclerosis. Bogie JF, Grajchen E, Wouters E, Broux B, Stinissen P, Van Wijmeersch B, Hendriks JJ. Ther Adv Chronic Dis. 2020 Aug 21;11:2040622320947378. doi: 10.1177/2040622320947378. eCollection 2020.

CD36-mediated uptake of myelin debris by macrophages and microglia reduces neuroinflammation. Grajchen E, Wouters E, van de Haterd B, Haidar M, Hardonnière K, Dierckx T, Van Broeckhoven J, Erens C, Hendrix S, Kerdine-Römer S, Hendriks JJA, Bogie JFJ. J Neuroinflammation. 2020 Jul 27;17(1):224. doi: 10.1186/s12974-020-01899-x.

Extracellular vesicle-associated lipids in central nervous system disorders. Vanherle S, Haidar M, Irobi J, Bogie JFJ, Hendriks JJA. Adv Drug Deliv Rev. 2020;159:322-331. doi: 10.1016/j.addr.2020.04.011. Epub 2020 May 1.

Stearoyl-CoA desaturase-1 impairs the reparative properties of macrophages and microglia in the brain. Bogie JFJ, Grajchen E, Wouters E, Corrales AG, Dierckx T, Vanherle S, Mailleux J, Gervois P, Wolfs E, Dehairs J, Van Broeckhoven J, Bowman AP, Lambrichts I, Gustafsson JÅ, Remaley AT, Mulder M, Swinnen JV, Haidar M, Ellis SR, Ntambi JM, Zelcer N, Hendriks JJA. J Exp Med. 2020 May 4;217(5):e20191660. doi: 10.1084/jem.20191660.

Fatty acid metabolism in the progression and resolution of CNS disorders. Bogie JFJ, Haidar M, Kooij G, Hendriks JJA. Adv Drug Deliv Rev. 2020;159:198-213. doi: 10.1016/j.addr.2020.01.004. Epub 2020 Jan 25.

Evaluation of lipid coverage and high spatial resolution MALDI-imaging capabilities of oversampling combined with laser post-ionisation. Bowman AP, Bogie JFJ, Hendriks JJA, Haidar M, Belov M, Heeren RMA, Ellis SR. Anal Bioanal Chem. 2020 Apr;412(10):2277-2289. doi: 10.1007/s00216-019-02290-3. Epub 2019 Dec 26.

2019

The Impact of Phytosterols on the Healthy and Diseased Brain. Dierckx T, Bogie JFJ, Hendriks JJA. Curr Med Chem. 2019;26(37):6750-6765. doi: 10.2174/0929867325666180706113844.

ADAM17-deficiency on microglia but not on macrophages promotes phagocytosis and functional recovery after spinal cord injury. Sommer D, Corstjens I, Sanchez S, Dooley D, Lemmens S, Van Broeckhoven J, Bogie J, Vanmierlo T, Vidal PM, Rose-John S, Gou-Fabregas M, Hendrix S. Brain Behav Immun. 2019 Aug;80:129-145. doi: 10.1016/j.bbi.2019.02.032. Epub 2019 Mar 6.

Liver X Receptor Alpha Is Important in Maintaining Blood-Brain Barrier Function. Wouters E, de Wit NM, Vanmol J, van der Pol SMA, van Het Hof B, Sommer D, Loix M, Geerts D, Gustafsson JA, Steffensen KR, Vanmierlo T, Bogie JFJ, Hendriks JJA, de Vries HE. Front Immunol. 2019 Jul 31;10:1811. doi: 10.3389/fimmu.2019.01811. eCollection 2019.

Dietary Sargassum fusiforme improves memory and reduces amyloid plaque load in an Alzheimer's disease mouse model. Bogie J, Hoeks C, Schepers M, Tiane A, Cuypers A, Leijten F, Chintapakorn Y, Suttiyut T, Pornpakakul S, Struik D, Kerksiek A, Liu HB, Hellings N, Martinez-Martinez P, Jonker JW, Dewachter I, Sijbrands E, Walter J, Hendriks J, Groen A, Staels B, Lütjohann D, Vanmierlo T, Mulder M. Sci Rep. 2019 Mar 20;9(1):4908. doi: 10.1038/s41598-019-41399-4.

2018

The physiology of foamy phagocytes in multiple sclerosis. Grajchen E, Hendriks JJA, Bogie JFJ. Acta Neuropathol Commun. 2018 Nov 19;6(1):124. doi: 10.1186/s40478-018-0628-8.

Western lifestyle and immunopathology of multiple sclerosis. Matveeva O, Bogie JFJ, Hendriks JJA, Linker RA, Haghikia A, Kleinewietfeld M. Ann N Y Acad Sci. 2018 Apr;1417(1):71-86. doi: 10.1111/nyas.13583. Epub 2018 Jan 27.

Active liver X receptor signaling in phagocytes in multiple sclerosis lesions. Mailleux J, Vanmierlo T, Bogie JF, Wouters E, Lütjohann D, Hendriks JJ, van Horssen J. Mult Scler. 2018 Mar;24(3):279-289. doi: 10.1177/1352458517696595. Epub 2017 Feb 1.

CD169 is a marker for highly pathogenic phagocytes in multiple sclerosis. Bogie JF, Boelen E, Louagie E, Delputte P, Elewaut D, van Horssen J, Hendriks JJ, Hellings N. Mult Scler. 2018 Mar;24(3):290-300. doi: 10.1177/1352458517698759. Epub 2017 Mar 9.

Twelve Weeks of Medium-Intensity Exercise Therapy Affects the Lipoprotein Profile of Multiple Sclerosis Patients. Jorissen W, Vanmierlo T, Wens I, Somers V, Van Wijmeersch B, Bogie JF, Remaley AT, Eijnde BO, Hendriks JJA. Int J Mol Sci. 2018 Jan 8;19(1):193. doi: 10.3390/ijms19010193.

Human Wharton's Jelly-Derived Stem Cells Display a Distinct Immunomodulatory and Proregenerative Transcriptional Signature Compared to Bone Marrow-Derived Stem Cells. Donders R, Bogie JFJ, Ravanidis S, Gervois P, Vanheusden M, Marée R, Schrynemackers M, Smeets HJM, Pinxteren J, Gijbels K, Walbers S, Mays RW, Deans R, Van Den Bosch L, Stinissen P, Lambrichts I, Gyselaers W, Hellings N. Stem Cells Dev. 2018 Jan 15;27(2):65-84. doi: 10.1089/scd.2017.0029. Epub 2017 Dec 21.

2017

Low-Density Lipoprotein Receptor Deficiency Attenuates Neuroinflammation through the Induction of Apolipoprotein E. Mailleux J, Timmermans S, Nelissen K, Vanmol J, Vanmierlo T, van Horssen J, Bogie JFJ, Hendriks JJA. Front Immunol. 2017 Nov 30;8:1701. doi: 10.3389/fimmu.2017.01701. eCollection 2017

Crosstalk with Inflammatory Macrophages Shapes the Regulatory Properties of Multipotent Adult Progenitor Cells. Ravanidis S, Bogie JFJ, Donders R, Deans R, Hendriks JJA, Stinissen P, Pinxteren J, Mays RW, Hellings N. Stem Cells Int. 2017;2017:2353240. doi: 10.1155/2017/2353240. Epub 2017 Jul 12.

Scavenger receptor collectin placenta 1 is a novel receptor involved in the uptake of myelin by phagocytes. Bogie JF, Mailleux J, Wouters E, Jorissen W, Grajchen E, Vanmol J, Wouters K, Hellings N, van Horssen J, Vanmierlo T, Hendriks JJ. Sci Rep. 2017 Mar 20;7:44794. doi: 10.1038/srep44794.

Relapsing-remitting multiple sclerosis patients display an altered lipoprotein profile with dysfunctional HDL. Jorissen W, Wouters E, Bogie JF, Vanmierlo T, Noben JP, Sviridov D, Hellings N, Somers V, Valcke R, Vanwijmeersch B, Stinissen P, Mulder MT, Remaley AT, Hendriks JJ. Sci Rep. 2017 Feb 23;7:43410. doi: 10.1038/srep43410.

2011-2016
 

Neuroinflammatory signals enhance the immunomodulatory and neuroprotective properties of multipotent adult progenitor cells. Ravanidis S, Bogie JF, Donders R, Craeye D, Mays RW, Deans R, Gijbels K, Bronckaers A, Stinissen P, Pinxteren J, Hellings N. Stem Cell Res Ther. 2015 Sep 16;6(1):176. doi: 10.1186/s13287-015-0169-z.

Plant sterols: Friend or foe in CNS disorders? Vanmierlo T, Bogie JF, Mailleux J, Vanmol J, Lütjohann D, Mulder M, Hendriks JJ. Prog Lipid Res. 2015 Apr;58:26-39. doi: 10.1016/j.plipres.2015.01.003. Epub 2015 Jan 24.

Human Wharton's Jelly-Derived Stem Cells Display Immunomodulatory Properties and Transiently Improve Rat Experimental Autoimmune Encephalomyelitis. Donders R, Vanheusden M, Bogie JF, Ravanidis S, Thewissen K, Stinissen P, Gyselaers W, Hendriks JJ, Hellings N. Cell Transplant. 2015;24(10):2077-98. doi: 10.3727/096368914X685104. Epub 2014 Oct 10.

Macrophage subsets and microglia in multiple sclerosis. Bogie JF, Stinissen P, Hendriks JJ. Acta Neuropathol. 2014 Aug;128(2):191-213. doi: 10.1007/s00401-014-1310-2. Epub 2014 Jun 22.

Heat-transfer resistance measurement method (HTM)-based cell detection at trace levels using a progressive enrichment approach with highly selective cell-binding surface imprints. Bers K, Eersels K, van Grinsven B, Daemen M, Bogie JF, Hendriks JJ, Bouwmans EE, Püttmann C, Stein C, Barth S, Bos GM, Germeraad WT, De Ceuninck W, Wagner P. Langmuir. 2014 Apr 1;30(12):3631-9. doi: 10.1021/la5001232. Epub 2014 Mar 19.

Myelin alters the inflammatory phenotype of macrophages by activating PPARs. Bogie JF, Jorissen W, Mailleux J, Nijland PG, Zelcer N, Vanmierlo T, Van Horssen J, Stinissen P, Hellings N, Hendriks JJ. Acta Neuropathol Commun. 2013 Aug 2;1:43. doi: 10.1186/2051-5960-1-43.

High fat diet exacerbates neuroinflammation in an animal model of multiple sclerosis by activation of the Renin Angiotensin system. Timmermans S, Bogie JF, Vanmierlo T, Lütjohann D, Stinissen P, Hellings N, Hendriks JJ. J Neuroimmune Pharmacol. 2014 Mar;9(2):209-17. doi: 10.1007/s11481-013-9502-4. Epub 2013 Sep 26.

Selective identification of macrophages and cancer cells based on thermal transport through surface-imprinted polymer layers. Eersels K, van Grinsven B, Ethirajan A, Timmermans S, Jiménez Monroy KL, Bogie JF, Punniyakoti S, Vandenryt T, Hendriks JJ, Cleij TJ, Daemen MJ, Somers V, De Ceuninck W, Wagner P. ACS Appl Mater Interfaces. 2013 Aug 14;5(15):7258-67. doi: 10.1021/am401605d. Epub 2013 Jul 17.

Local overexpression of interleukin-11 in the central nervous system limits demyelination and enhances remyelination. Maheshwari A, Janssens K, Bogie J, Van Den Haute C, Struys T, Lambrichts I, Baekelandt V, Stinissen P, Hendriks JJ, Slaets H, Hellings N. Mediators Inflamm. 2013;2013:685317. doi: 10.1155/2013/685317. Epub 2013 May 30.

Myelin-derived lipids modulate macrophage activity by liver X receptor activation. Bogie JF, Timmermans S, Huynh-Thu VA, Irrthum A, Smeets HJ, Gustafsson JÅ, Steffensen KR, Mulder M, Stinissen P, Hellings N, Hendriks JJ. PLoS One. 2012;7(9):e44998. doi: 10.1371/journal.pone.0044998. Epub 2012 Sep 12.

Myelin-phagocytosing macrophages modulate autoreactive T cell proliferation. Bogie JF, Stinissen P, Hellings N, Hendriks JJ. J Neuroinflammation. 2011 Jul 25;8:85. doi: 10.1186/1742-2094-8-85.

Location

Hasselt University 

Biomedical Research Institute

Department of Immunology and Infection

Agoralaan Building C
3590 Diepenbeek

Belgium

Get in Touch

Jeroen.bogie@uhasselt.be

+32-(0)11-269261

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